ViaPragma Confidential by design
No. 001 · For pharma, biobanks & clinical research
A research bulletin from ViaPragma

Compute moves.
Data stays put.
Trust gets proven.

We're building an attested compute layer for healthcare's hardest collaboration problems — where neither party can afford to share their data, and contracts alone aren't enough.

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ViaPragma SECURE ENCLAVE 9,072 records data home model home imaging model
In motion · 9-second cycle
9,072 RECORDS IMAGING MODEL ViaPragma SECURE ENCLAVE DATA HOME MODEL HOME

Three workflows where current tools quietly fail.

i.

Pharma models
at the hospital edge

A pharma company has a proprietary imaging or genomics model. A hospital has the patient data. Neither will move first. Federated learning helps with training — but inference on real patients leaks both ways. We think attestation closes the gap.

Design partnersPharma R&D IT, hospital CMIOs
Pain12–18 mo data deals per site
ii.

Multi-site trials
with imaging endpoints

Sponsors need blinded reads. Sites can't share raw scans laterally. Core labs become a bottleneck and a single point of trust. Decentralized blinded reads — with cryptographic proof of what ran where — reshape the workflow.

Design partnersCROs, sponsors, core labs
PainCentralization risk & latency
iii.

Cross-border
genomic biobanks

National programs and disease consortia want to collaborate but can't legally co-locate data. Federation helps. Hardware attestation gives the audit story regulators in EU, Singapore, India, and elsewhere increasingly ask for by name.

Design partnersBiobank CTOs, ministry programs
PainSovereignty & audit demands
Our position

Federation is necessary.
It is not sufficient.

Three layers of healthcare data risk and what each technology covers Threat surface Federation covers Attestation adds 01 Data in motion Sharing raw records across institutions Data stays put 02 Model & code integrity What ran. On whose data. With what version. Trust me bro Cryptographic proof 03 Data in use Memory, gradients, intermediate state at runtime Exposed Hardware-sealed A reasonable answer in 2018. The threat model has moved on.
01

Data in motion

Sharing raw records across institutions

Federation covers Data stays put
Attestation adds
02

Model & code integrity

What ran. On whose data. With what version.

Federation covers Trust me bro
Attestation adds Cryptographic proof
03

Data in use

Memory, gradients, intermediate state at runtime

Federation covers Exposed
Attestation adds Hardware-sealed

A reasonable answer in 2018. The threat model has moved on.

What attestation adds that federation alone won't.

Model IP, sealed

Federation alone leaks gradients. Weights can be reconstructed.

With attestation, the host institution sees only ciphertext.

Code, provable

Trust is contractual. Audit logs come after the fact.

Cryptographic proof that exactly the agreed code ran.

Regulator-ready

"Data didn't move" — defensible, but increasingly thin.

Hardware-rooted evidence aligned with EHDS & FedRAMP.

Inference, first-class

Most platforms focus on training collaboration only.

Designed for production at hospital sites and trial centers.

If any of these describe you — we owe you coffee.

  • You run R&D IT or data science at a top-50 pharma
  • You operate a national or regional biobank
  • You lead imaging or pathology operations at an AMC
  • You deploy clinical AI into hospital systems
  • You run imaging endpoints for a CRO or sponsor
  • You're a regulator or policy advisor in this space
Discovery call · 30 min · Zoom or in person

Tell us where the seams are.

Five fields. We'll reply within two business days with a few times. If the fit isn't there, we'll say so plainly.

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RECEIVED Thank you. We'll be in touch within two business days with a few suggested times. If for any reason this isn't a fit on our end, we'll write back and tell you why.